Transcriptional Response of Multi-Stress-Tolerant Saccharomyces cerevisiae to Sequential Stresses

During the fermentation process, yeast cells face different stresses, and their survival efficiency depend on adaptation to these challenging conditions. Yeast must tolerate not only a single stress but also multiple simultaneous sequential stresses. However, cellular response when are sequentially stressed completely understood. To explore this, we exposed multi-stress-tolerant strain (BT0510) consecutive stresses globally common response, focusing genes induced in both Gene Ontology, pathway analyses, transcription factor motifs identified many processes linked this response. A metabolic shift pentose phosphate pathway, peroxisome activity, oxidative were some of found. The SYM1, STF2, HSP factors Adr1 Usv1 may play role This study presents global view transcriptome multi-resistance provides new insights into can indicate future directions for genetic engineering strains, which could improve processes, such as those used bioethanol production beverages.